| Name | (-)-Catechin gallate | ||
| PubChem CID | 6419835 | ||
| Molecular Weight | 442.4g/mol | ||
| Formula | C₂₂H₁₈O₁₀ | ||
| SMILES | C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O | ||
| InChI | 1S/C22H18O10/c23-11-6-14(25)12-8-19(32-22(30)10-4-16(27)20(29)17(28)5-10)21(31-18(12)7-11)9-1-2-13(24)15(26)3-9/h1-7,19,21,23-29H,8H2/t19-,21+/m1/s1 | ||
| InChIKey | LSHVYAFMTMFKBA-CTNGQTDRSA-N | ||
| CAS Number | 130405-40-2 | ||
| ChEMBL ID | CHEMBL129451 | ||
| ChEBI ID | CHEBI:76131 | ||
| Structure | 
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2D
MOL
3D
MOL
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| Chineses Pinyin | FuPenZi | ||
| Use Part | Aggregate Fruit | ||
| Habitat | AnHui, JiangSu, ZheJiang | ||
| Flavor | Sweet, Sour | ||
| Meridian Tropism | Liver, Kidney, Bladder | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Rosales
-->Family: Rosaceae
-->Genus: Rubus
-->Species: Rubus chingii
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| Chineses Pinyin | Cha | ||
| Use Part | Tender leaf or tender bud | ||
| Habitat | JiangSu, AnHui, ZheJiang, JiangXi, HuBei, SiChuan, GuiZhou, YunNan, Shaanxi | ||
| Flavor | Sweet; Bitter | ||
| Meridian Tropism | Lung; Stomach; Heart | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Ericales
-->Family: Theaceae
-->Genus: Camellia
-->Species: Camellia sinensis
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| Pair Name | (-)-Catechin gallate, Sorafenib | |||
| Partner Name | Sorafenib | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Inhibition-->Angiogenesis | |||
| Gene Regulation | Down-regulation | Expression | VEGFA | hsa7422 |
| In Vivo Model | Rats were randomized and allocated into four groups, consisting of 7 rats, except the control (K) group, which contained four rats, with a minimal sample size of three. Subsequently, DEN was injected intraperitoneally in the abdominal area below the umbilicus on 21 rats for two treatment groups and a control group, with 70 mg/kg BW/week for ten weeks. | |||
| Result | Standard-dose Sorafenib and the combination of low-dose Sorafenib and epigallo-3-catechin gallate have similar effectivity in reducing the expression of microvascular density and could prevent resistance and lower toxicity effects. | |||
